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Description

Yeasen visits laboratories in Europe with your local Gentaur representative. 

Yeasen CleaScrip™ Custom mRNA Synthesis (Low dsRNA) 

Service description

Yeasen’s CleaScrip™ Custom mRNA Synthesis (Low dsRNA) is a tailored in vitro transcription (IVT) service delivering high-quality mRNA with ultra-low dsRNA content, suitable for research and preclinical applications.

Key features

  • Ultra-low dsRNA (~0.02 ng/µg), reducing innate immune activation
  • Cap1 mRNA (>90% capping efficiency)
  • Poly(A) tail ~100 nt (customizable)
  • High integrity and yield, HPLC-purified
  • Optional modified nucleotides (e.g. pseudouridine, 5-mC)

Applications

  • mRNA functional studies
  • Vaccine and therapeutic research
  • Primary cells, stem cells, and sensitive models
  • Downstream LNP formulation workflows

Workflow

  1. Sequence / project definition
  2. Template preparation and IVT using CleaScrip™ low-dsRNA polymerase
  3. Purification and QC
  4. Delivery of ready-to-use mRNA with documentation

Distribution & support (Gentaur)

  • Service available through Gentaur as Yeasen distributor
  • Gentaur technical representative can visit laboratories to:
    • Discuss experimental needs and design
    • Answer technical questions
    • Support project setup and follow-up
  • Gentaur coordinates quotations, timelines, and communication with Yeasen

Deliverables

  • Purified low-dsRNA mRNA
  • QC data (yield, integrity, dsRNA level)
  • Research-use documentation